Bcl-xL
TRANSMEMBRANE MOLECULE IN THE MITOCHONDRIA
Bcl-xl; Bcl-Xl; Bcl-XL
B-cell lymphoma-extra large (Bcl-xL), encoded by the BCL2-like 1 gene, is a transmembrane molecule in the mitochondria. It is a member of the Bcl-2 family of proteins, and acts as an anti-apoptotic protein by preventing the release of mitochondrial contents such as cytochrome c, which leads to caspase activation and ultimately, programmed cell death.